- Earth 2140
- Earthworm Jim
- Earthworm Jim 2
- EcoQuest: The Search for Cetus
- Ečstatica
- Endzone: A World Apart
- EF 2000
- eFootball PES 2021
- Elder Scrolls I: Arena, The
- Elder Scrolls II: Daggerfall, The
- Elder Scrolls III: Morrowind, The
- Elder Scrolls IV: Oblivion, The
- Elder Scrolls V: Skyrim, The
- Elder Scrolls V: Skyrim VR, The
- Elder Scrolls Online, The
- Electroman
- Elements
- Eleven: Table Tennis VR
- Elex
- Elite Dangerous
- Emergency: Fighters for Life
- Emmanuelle: A Game of Eroticism
- Empire of Sin
- Engine Evolution
- Enlisted
- Entity
- Epic
- Epic Roller Coasters
- Eric the Unready
- Escape from Delirium
- Escape from Tarkov
- Eternal Card Game
- Eternam
- Euro Truck Simulator 2
- EVE Online
- Evil Genius
- Evil Genius 2: World Domination
- Eye of the Beholder
- Eye of the Beholder II: The Legend of Darkmoon
- Eye of the Beholder III: Assault on Myth Drannor