- Earth 2140
- Earthworm Jim
- Earthworm Jim 2
- Eastward
- EcoQuest: The Search for Cetus
- Ečstatica
- Endzone: A World Apart
- EF 2000
- eFootball PES 2021
- eFootball 2022
- Elden Ring
- Elder Scrolls I: Arena, The
- Elder Scrolls II: Daggerfall, The
- Elder Scrolls III: Morrowind, The
- Elder Scrolls IV: Oblivion, The
- Elder Scrolls V: Skyrim, The
- Elder Scrolls V: Skyrim VR, The
- Elder Scrolls Online, The
- Eldest Souls
- Electroman
- Elements
- Eleven: Table Tennis VR
- Elex
- Elite Dangerous
- Elyon
- Emergency: Fighters for Life
- Emmanuelle: A Game of Eroticism
- Empire of Sin
- Engine Evolution
- Enlisted
- Enter the Gungeon
- Entity
- Entropy: Zero 2
- Epic
- Epic Roller Coasters
- Eric the Unready
- Escape from Delirium
- Escape from Tarkov
- Eternal Card Game
- Eternal Return
- Eternam
- Eternium
- Euro Truck Simulator 2
- Europa Universalis IV
- EVE Online
- Everspace 2
- Evil Genius
- Evil Genius 2: World Domination
- Expeditions: Rome
- Eye of the Beholder
- Eye of the Beholder II: The Legend of Darkmoon
- Eye of the Beholder III: Assault on Myth Drannor