- S.T.A.L.K.E.R.: Call of Pripyat
- S.T.A.L.K.E.R.: Clear Sky
- S.T.A.L.K.E.R.: Shadow of Chernobyl
- Sam & Max Hit the Road
- Scorched Earth
- Scrap Mechanic
- SCUM
- Secret Agent
- Secret Island of Dr. Quandary, The
- Secret of Monkey Island, The
- Sekiro: Shadows Die Twice
- Sensible Soccer: European Champions
- Sensible World of Soccer
- Serf City: Life is Feudal (a.k.a. The Settlers)
- Shadow Knights
- Shadow of the Tomb Raider
- Sharkey’s 3D Pool
- Sid Meier’s Alpha Centauri
- Sid Meier’s Civilization
- Sid Meier’s Civilization II
- Sid Meier’s Colonization
- Silent Service
- Silent Service 2
- SimAnt: The Electronic Ant Colony
- SimCity
- SimCity 2000
- SimEarth: The Living Planet
- SimFarm
- SimIsle: Missions in the Rainforest
- SimLife
- Simon the Sorcerer
- SimPark
- Simpsons Arcade Game, The
- Simpsons: Bart vs. the Space Mutants, The
- SimTower: The Vertical Empire
- SimTown
- Skate or Die
- Ski or Die
- SkyRoads
- Sleepwalker
- Sniper Elite 3
- Sniper Elite 4
- Soccer Kid
- Sokoban
- Soldat
- Sonic CD
- Space Crusade
- Space Invaders
- Space Engineers
- Spear of Destiny
- Speedball
- Speedball 2: Brutal Deluxe
- Spellcross
- Stalker Online
- Star Conflict
- Star Control II
- Star Trek: Judgment Rites
- Star Wars
- Star Wars: Battlefront II (2017)
- Star Wars: Dark Forces
- Star Wars Chess
- Star Wars: Tie Fighter
- Star Wars: X-Wing
- Star Wars Jedi: Fallen Order
- StarCraft 2
- Stargoose Warrior
- Stars!
- Steel Panthers
- Steg the Slug
- Street Fighter
- Street Fighter II
- Street Rod
- Street Rod 2: The Next Generation
- Strife
- Strip Poker 3
- Stronghold
- Stunts
- Subnautica
- Summer Challenge
- Summoning, The
- Supaplex
- Super Mario Bros.
- SuperKarts
- Survarium
- Syndicate
- System Shock
- System Shock 2
