- UBOAT
- Ugh!
- Ultima
- Ultima I: The First Age of Darkness
- Ultima II: The Revenge of the Enchantress…
- Ultima III: Exodus
- Ultima IV: Quest of the Avatar
- Ultima Underworld: The Stygian Abyss
- Ultimate Admiral: Age of Sail
- Ultimate Body Blows
- Ultimate Cards
- Ultrabots (Xenobots)
- Ultris: The Ultimate Tetris
- Unravel
- Unreal
- Unreal 2: The Awakening
- Unreal Tournament
- Unreal Tournament 2003
- Unreal Tournament 2004
- Unreal Tournament III
- Until You Fall
- Unturned
- Utopia: The Creation of a Nation